Modulation of thiopental-induced vascular relaxation and contraction by perivascular adipose tissue and endothelium
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چکیده
منابع مشابه
Modulation of thiopental-induced vascular relaxation and contraction by perivascular adipose tissue and endothelium.
BACKGROUND Thiopental induces relaxation of vascular smooth muscle cells through its direct and/or indirect vasodilator effects. The perivascular adipose tissue (PVAT) and the endothelium are known to attenuate vascular contraction, and we have recently reported that PVAT potentiates the relaxation effect of propofol through endothelium-dependent and -independent mechanisms. Here, we studied th...
متن کاملPerivascular adipose tissue, vascular reactivity and hypertension.
Most blood vessels are surrounded by a variable amount of adventitial adipose tissue, perivascular adipose tissue (PVAT), which was originally thought to provide mechanical support for the vessel. It is now known that PVAT secretes a number of bioactive substances including vascular endothelial growth factor, tumor necrosis factor-alpha (TNF-α), leptin, adiponectin, insulin-like growth factor, ...
متن کاملPerivascular adipose tissue and coronary vascular disease.
Coronary perivascular adipose tissue is a naturally occurring adipose tissue depot that normally surrounds the major coronary arteries on the surface of the heart. Although originally thought to promote vascular health and integrity, there is a growing body of evidence to support that coronary perivascular adipose tissue displays a distinct phenotype relative to other adipose depots and is capa...
متن کاملEffects of hyperglycemia on the modulation of vascular function by perivascular adipose tissue.
OBJECTIVE To study the acute and chronic effect of hyperglycemia on perivascular adipose tissue (PVAT) function in rat aorta. METHOD Alterations in PVAT function in rat aorta incubated with 22 mmol/l D-glucose for 30 min and in aorta from streptozotocin (STZ)-induced diabetic rats were studied. RESULTS Incubation with D-glucose caused an attenuation of contraction in response to phenylephri...
متن کاملPerivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: influence of obesity.
BACKGROUND This investigation examined the mechanisms by which coronary perivascular adipose tissue (PVAT)-derived factors influence vasomotor tone and the PVAT proteome in lean versus obese swine. METHODS AND RESULTS Coronary arteries from Ossabaw swine were isolated for isometric tension studies. We found that coronary (P=0.03) and mesenteric (P=0.04) but not subcutaneous adipose tissue aug...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2012
ISSN: 0007-0912
DOI: 10.1093/bja/aes127